Lung Cancer Cell Lines As Tools For Biomedical Discovery And Research

A systematic approach to initiating and characterizing cell lines from small cell and non small cell lung carcinomas has led to the current collection of more than 200 lung cancer cell lines a number that exceeds those for other common epithelial cancers combined.

Lung cancer cell lines as tools for biomedical discovery and research.

While most cases arise in smokers lung cancer in lifetime never smokers is a major problem and for reasons we have reviewed may be considered a distinct entity lung cancers represent several histologic types and they may be divided into those arising from the central mainly small cell sclc or. A systematic approach to initiating and characterizing cell lines from small cell and non small cell lung carcinomas has led to the current collection of more than 200 lung cancer cell lines a number that exceeds those for other common epithelial cancers. Lung cancer cell lines are crucial for translational and biomedical research. Although human lung tumor derived cell lines play an important role in the investigation of lung cancer biology and genetics there is no comprehensive study comparing the genotypic and phenotypic properties of lung cancer cell lines with those of the individual tumors from which they were derived.

A systematic approach to initiating and characterizing cell lines from small cell and non small cell lung carcinomas has led to the current collection of more than 200 lung cancer cell lines a number that exceeds those. Lung cancer remains the commonest form of cancer deaths in the world. Lung cancer cell lines have made a substantial contribution to lung cancer translational research and biomedical discovery. Lung cancer cell lines as tools for biomedical discovery and research.

Human cancer cell lines are widely used in vitro models for studying cancer and its biology apart from being valuable tools for identifying biomarkers and genetic variants that impact drug sensitivities 2 3 cancer cell lines play a pivotal role in the early stages of drug discovery facilitating the screening of hundreds of potential drugs and their combinations before. Lung cancer cell lines have made a substantial contribution to lung cancer translational research and biomedical discovery. Lung cancer cell lines have made a substantial contribution to lung cancer translational research and biomedical discovery. Lung cancer cell lines as tools for biomedical discovery and research article literature review pdf available in journal of the national cancer institute 102 17 1310 21 september 2010.